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  • The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) in excess of 27, provided they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes showed that patients had an average weight loss of four years old.1% rather than participants who have been given placebos) within a 12- month period, while another study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err along the side of caution and permit the FDA do its job and demand some study be done in order that the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on the medications.

    Researchers discovered that participants investing in this drug for the year, lost weight within four weeks and have kept the extra weight off through the entire 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which are made up of many active ingredient, which might make them more effective and safer.

    Combo-pilling may be the newest fad or in addition to this the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular will be the fact that at the time of right now there aren't any long term prescription slimming capsules that have been authorized by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise hypertension and heartrate, and shouldn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

    Most of the combinations which can be used to enhance weight reduction involve an amphetamine with an antidepressant. Phentermine and Prozac certainly are a popular combination that have been around for quite a while, and even though it has been around stuffed to truly combine both and try to get FDA approval to advertise it as a weight reduction pill. Right there should raise some warning flag if the greedy pharmaceutical companies do not want to be involved in combining medications and selling them something has to be wrong with the combination. In fairness there exists one fat loss combination pill that's in front of the FDA now Contrave?which couples naltrexone, used to treat alcohol and abusing drugs, with all the antidepressant bupropion (Wellbutrin, Zyban) it has been given the go ahead to move forward by an FDA advisory committee, but by yet hasn't been approved.